Changes in tiny chemical tags on DNA (DNA methylation at CpG sites) can estimate a person’s biological age and even the pace of aging. Tools called epigenetic clocks read these patterns. One clock, DunedinPACE, was built mainly from European-ancestry data, so its performance in other groups has been uncertain. In our JAMA Network Open study of 376 Hawaiʻi adults (Japanese American, Native Hawaiian, and White), the average pace was 1.27—about 27% faster than the reference. Native Hawaiian participants had the highest mean (1.31) and the largest share classified as “fast” (56%). Faster pace tracked with higher BMI and lower neighborhood socioeconomic status, while a healthier diet and more years of education related to slower pace; notably, more moderate-to-vigorous physical activity predicted slower aging among Native Hawaiian adults. Together, the findings highlight both biological etiologies of disparities and modifiable avenues for prevention, warranting further study.