Since 2017, our research has focused on protecting Puerto Rican communities from arboviral diseases, including dengue, chikungunya, and Zika. Through large collaborative studies, we developed a clear guide for action: track infections as they occur, improve testing speed and reliability, identify who is most at risk, and implement home and neighborhood protections—such as window screens—that reduce mosquito bites and illness. This work has supported our local health department and community leaders in shaping prevention programs that fit Puerto Rico’s needs. It has also informed decisions on vaccine use and the development of new diagnostic tools. Our findings have also informed decisions on vaccine deployment strategies and the use of new diagnostic tools. Beyond public health impact, these projects have expanded training opportunities for students and professionals, building local expertise, strengthening Puerto Rico’s research capacity, and generating new jobs in science and community engagement. Together, this work advances health equity by reducing the burden of mosquito-borne illnesses while empowering communities with knowledge and resources to protect themselves.