Lupus remains a serious clinical challenge because available medications lack specificity for lupus autoimmunity, often impairing normal immune responses and affecting other essential body functions. Reinforcing immune tolerance has been recognized as a promising approach for selectively suppressing lupus autoimmunity; however, limited understanding of tolerance mechanisms has hindered satisfactory clinical outcomes. This review highlights existing strategies aimed at strengthening immune tolerance and emphasizes that restoring impaired B cell intrinsic tolerance may provide a more physiological and effective way to suppress lupus autoimmunity without compromising normal immunity or other critical functions.