Researchers have made a groundbreaking discovery that could revolutionize pain medicine by uncovering a treasure trove of bioactive compounds in jellyfish venom. This reveals that jellyfish contain numerous small proteins and peptides that can precisely control nerve cell activity. Using an advanced laboratory technique called "constellation pharmacology," the research team tested purified jellyfish venom components on mouse nerve cells that process pain signals, monitoring their responses through sophisticated calcium imaging technology. The results showed that these venom compounds produced three distinct, dose-dependent effects on different types of nerve cells, and importantly, these effects were completely reversible. The compounds appear to work by targeting specific molecular gates on nerve cells that control electrical signaling, suggesting they could be developed into a new class of painkillers. This discovery not only opens up jellyfish as an entirely new source for pharmaceutical development but also demonstrates the untapped potential of marine organisms in creating safer, more effective medications for treating pain and neurological conditions.