Research Development Core Pilot Projects Program, "Investigation of Synergistic Impact of Environmental Toxicant and High Fat Diet in Hepatocellular Carcinoma (HCC)"

Research Areas

  • Early cancer detection biomarkers for GI Cancers
  • Systems Biology and Environmental Toxicology

Scientific Achievements

  • Dr. Dhasmana has identified a novel fetal-onco protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), which is expressed only in pancreatic cancer, especially in the early stages.
  • He has worked on other biomarkers like MUC13 and TRIP13 on pancreatic and other GI cancers.
  • He has published several research articles using an integrative biology approach (Bioinformatic and Molecular Biology) in the field of cancer biology, environmental toxicology, and nano-biotechnology.

Funding

RCMI Funding

  • U54MD019970 Pilot Project: "Investigation of Synergistic Impact of Environmental Toxicant and High Fat Diet in Hepatocellular Carcinoma (HCC)"

Scientific Advance

CEACAM7 expression contributes to early events of pancreatic cancer.
Published in Journal of Advanced Research, Volume 55, January 2024, Pages 61-72. PMID: 36828119; PMCID: PMC10770095.
As the incidence and mortality rates of pancreatic cancer continue to rise, it is projected to become the second leading cause of cancer-related deaths in the United States by 2030. Pancreatic cancer has a poor prognosis, with a mortality rate very close to its incidence rate, largely due to the lack of early detection methods and effective therapeutic regimens. In response to this urgent clinical need, our team published this research identifying a novel fetal-onco protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), which is expressed only in pancreatic cancer, especially in the early stages.
Toggle Navigation