Research Capacity Core - Neurogenetics and Bioimaging Facility
Research Areas
- Neuro-parasitology
- Neurobiology of motor systems
- Schistosomiasis
Scientific Achievements
- Identified novel neuropeptides in the nervous system of Biomphalaria, the intermediate host for schistosomiasis.
- Characterized a ligand-gated channel activated by a neuropeptide.
- Examined interactions between a central pattern generator motor circuit and the muscle system that it innervates.
Funding
RCMI Funding:
- NIH/NIMHD U54MD007600
Other funding obtained with RCMI support:
- W911NF-24-1-0330, DoD, Acquisition of a Laser Scanning Confocal Microscope at the University of Puerto Rico
- IOS-2217657, NSF, Host Manipulation by Parasites: Neurobiological Substrates
- GM103642, NIH NIGMS, COBRE: Center for Neuroplasticity at the University of Puerto Rico
Scientific Advance
Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis.
Published in Journal of Comparative Neurology, Volume 533, 2025, PMCID: PMC11841659.
Published in Journal of Comparative Neurology, Volume 533, 2025, PMCID: PMC11841659.
This research mapped out where in the nervous system of Biomphalaria glabrata (a freshwater snail that spreads schistosomiasis) the neuropeptides Cholecystokinin (CCK) / Sulfakinin are located. Using immunohistochemistry and mRNA labeling, they found that both the peptide itself and the mRNA encoding it are expressed in clusters of neurons within the snail’s central nervous system; the mRNA was seen mainly in neuron cell bodies, while the peptide is also found in neuronal fibers. Because CCK/Sulfakinin is known in other animals to regulate feeding, digestion, and possibly immune responses, knowing where these neuropeptides are in B. glabrata could help us understand how infection affects snail behavior or physiology, which may be relevant in efforts to control schistosomiasis.
U54 MD007600/ NIMHD NIH HHS/United States, P30 GM149367/ NIGMS NIH HHS/United States, P30GM149367/NIH HHS/United States, OISE-1545803/National Science Foundation, HRD-1137725/National Science Foundation, IOS-217657/National Science Foundation, DBI-1337284/National Science Foundation
