Lung cancer is the leading cause of cancer deaths, and some groups—such as Native Hawaiian and African American communities—face a higher risk and worse outcomes. Current screening methods, like CT scans, often give false results, leading to unnecessary tests and stress. Our research is developing a simple blood test that looks at tiny particles called exosomes, which carry genetic signals from cancer cells. We have already identified a set of RNA markers in these exosomes that can detect lung cancer with very high accuracy. In this project, we will test these markers in diverse populations and study how they affect cancer cell metabolism. This work could lead to better early detection, more effective treatments, and help reduce health disparities in lung cancer.