This study surveyed nearly 1,900 adults in Puerto Rico in late 2020 through early 2021 to understand how much people’s religious beliefs and importance they place on religion relate to their attitudes about COVID-19 vaccination and their intent to get vaccinated. The findings show that people who view religion as “very important” are more likely to be uncertain or unwilling to receive the vaccine compared to those who consider religion less important. Those same individuals also report feeling less susceptible to COVID-19, seeing more barriers to vaccination, and perceiving fewer benefits from the vaccine. On the other hand, many also said they would consider vaccination if they had better information or if more people in their community got vaccinated. These results suggest that vaccine promotion campaigns in Puerto Rico may need special attention to the religious community, especially ensuring clear, trustworthy information and leveraging community norms.